Wednesday, July 14, 2021

2017 article in a Nature journal discusses ivermectin effects (even against cancer) and mechanisms of action.

Someone wrote this in 2017.  Some people thus knew ivermectin had antiviral properties.  In fact, the drug has all kinds of possibly miraculous effects.  It is just missing the important one:  patentability.  (It was patented but the patent expired in 1997.) 

Recent research has confounded the belief, held for most of the past 40 years, that ivermectin was devoid of any antiviral characteristics. Ivermectin has been found to potently inhibit replication of the yellow fever virus, with EC50 values in the sub-nanomolar range. It also inhibits replication in several other flaviviruses, including dengue, Japanese encephalitis and tick-borne encephalitis, probably by targeting non-structural 3 helicase activity.97 Ivermectin inhibits dengue viruses and interrupts virus replication, bestowing protection against infection with all distinct virus serotypes, and has unexplored potential as a dengue antiviral.98 Ivermectin has also been demonstrated to be a potent broadspectrum specific inhibitor of importin α/β-mediated nuclear transport and demonstrates antiviral activity against several RNA viruses by blocking the nuclear trafficking of viral proteins. It has been shown to have potent antiviral action against HIV-1 and dengue viruses, both of which are dependent on the importin protein superfamily for several key cellular processes. Ivermectin may be of import in disrupting HIV-1 integrase in HIV-1 as well as NS-5 (non-structural protein 5) polymerase in dengue viruses.99,100...


There is a continuously accumulating body of evidence that ivermectin may have substantial value in the treatment of a variety of cancers. The avermectins are known to possess pronounced antitumor activity,107 as well as the ability to potentiate the antitumor action of vincristine on Ehrlich carcinoma, melanoma B16 and P388 lymphoid leukemia, including the vincristine-resistant strain P388.108 Over the past few years, there have been steadily increasing reports that ivermectin may have varying uses as an anti-cancer agent, as it has been shown to exhibit both anti-cancer and anti-cancer stem cell properties. An in silico chemical genomics approach designed to predict whether any existing drugs might be useful in tackling glioblastoma, lung and breast cancer, indicated that ivermectin may be a useful compound in this respect.109 In human ovarian cancer and NF2 tumor cell lines, high-dose ivermectin inactivates protein kinase PAK1 and blocks PAK1- dependent growth. PAK proteins are essential for cytoskeletal reorganization and nuclear signaling, PAK1 being implicated in tumor genesis while inhibiting PAK1 signals induces tumor cell apoptosis (cell death). PAK1 is essential for the growth of more than 70% of all human cancers, including breast, prostate, pancreatic, colon, gastric, lung, cervical and thyroid cancers, as well as hepatoma, glioma, melanoma, multiple myeloma and for neurofibromatosis tumors.110 Globally, breast cancer is the most common cancer among women but treatment options are few. Ivermectin suppresses breast cancer by activating cytostatic autophagy, disrupting cellular signaling in the process, probably by reducing PAK1 expression...


Anonymous said...

1. COVID-19 cure already discovered? Ivermectin ‘can end this pandemic’
2. Review of the Emerging Evidence Demonstrating the Efficacy of Ivermectin in the Prophylaxis and Treatment of COVID-19!
3. FDA-approved anti-parasitic drug ivermectin can kill the coronavirus within 48 hours, reports new study.
4. New York Supreme Court Judge Saves 80-Year-Old Patient from Death by Ordering Hospital to Give Life-Saving Ivermectin!
5. Pushing vaccines while banning ivermectin is “global collusion” to cause as much harm and death as possible.

Anonymous said...

Meryl, what can you say about this?:

Meryl Nass, M.D. said...

As detailed in my long paper of 58 ways hydroxychloroquine has been suppressed for Covid, a similar suppression is underway to restrict use of ivermectin.

Standards of medical publication vary acros the world. This paper from Egypt is of low quality--perhaps some is plagiarized. (Someone plagiarized sentences from a paper of mine once, so it may be a common though unacceptable practice.)

Ignore this paper. There are 60 others, and 2 important reviews of the ivermectin literature have recently been published, by Andrew Hill and Tess Lawrie. The drug works. And some bad actors wish it didn't and are pulling out all the stops to tank it.