Saturday, June 27, 2020

How a false hydroxychloroquine narrative was created, and more

It is remarkable that a series of events taking place over the past 3 months produced a unified message about hydroxychloroquine, and produced similar policies about the drug in the US, Canada, Australia, NZ and western Europe.  The message is that generic, inexpensive hydroxychloroquine is dangerous and should not be used to treat a potentially fatal disease, Covid-19, for which there are no (other) reliable treatments. 

Hydroxychloroquine has been used safely for 65 years in many millions of patients.  And so the message was crafted that the drug is safe for its other uses, but dangerous when used for Covid-19.  It doesn't make sense, but it seems to have worked.

Were these acts carefully orchestrated?  You decide.

Might these events have been planned to keep the pandemic going?  To sell expensive drugs and vaccines to a captive population?   Could these acts result in prolonged economic and social hardship, eventually transferring wealth from the middle class to the very rich?  Are these events evidence of a conspiracy?

Here is a list of what happened, in no special order. Please help add to this list if you know of other actions I should include.  This will be a living document.  I have penned this as if it is the "to do" list of items to be carried out by those who pull the strings.  The items on the list have already been carried out.  One wonders what else might be on their list, yet to be carried out, for this pandemic.

1.  You stop doctors from using the drug in ways it is most likely to be effective (in outpatients at onset of illness).  You prohibit use outside of situations you can control.  

Situations that were controlled to show no benefit included 3 large, randomized, multi-center clinical trials (Recovery, Solidarity and REMAP-Covid), the kind of trials that are generally believed to yield the most reliable evidence. However, each of them used excessive hydroxychloroquine doses that were known to be toxic and may have been fatal in some cases; see my previous articles here and here.

2.  You prevent or limit use in outpatients by controlling the supply of the drug, using different methods in different countries and states.  In NY state, by order of the governor, hydroxychloroquine could only be prescribed for hospitalized patients.  France has issued a series of different regulations to limit prescribers from using it.  France also changed the drugs' status from over-the-counter to a drug requiring a prescription.

3.  You play up the danger of the drug, emphasizing side effects that are very rare when the drug is used correctly. You make sure everyone has heard about the man who died after consuming hydroxychloroquine in the form of fish tank cleaner. 

4.  You limit clinical trials to hospitalized patients, instead of testing the drug in outpatients, early in the illness, when it is predicted to be most effective.

5.  You design clinical trials to give much too high a dose, ensuring the drug will cause harm in some subjects, sufficient to mask any possible beneficial effect.  You make sure that trials in 400 hospitals in 35 countries use these dangerous doses.

6.  You design clinical trials to collect almost no safety data, so any cause of death due to drug toxicity will be attributed to the disease instead of the drug.

7.  You issue rules for use of the drug based on the results of the UK Recovery study, which overdosed patients. Of course the Recovery results showed more deaths in the hydroxychloroquine arm, since they gave patients 2.4 g in the first 24 hrs, 800 mg/day thereafter. Furthermore, the UK has the 2nd highest death rate in the world for Covid-19 (Belgium is 1st), so simply conducting the trial in the UK may have contributed to the poor results. 

8.  You publish, in the world's most-read medical journal, the Lancet, an observational study from a huge worldwide database (96,000 Covid cases) that says use of chloroquine drugs caused significantly increased mortality.  You make sure that all major media report on this result. Then you have 3 European countries announce they will not allow doctors to prescribe the drug.

9.  You do your best to ride out any controversy, never admitting culpability.  Even after hundreds of people renounced the Lancet's observational study due to easily identified fabrications--the database used in the study did not exist, and the claimed numbers did not agree with known numbers of cases--the Lancet held firm for two weeks, serving to muddy the waters about the trial, until finally 3 of its 4 coauthors (but not the journal) retracted the study. But neither the authors nor the journal admitted responsibility. You make sure very few media report that the data were fabricated and the "study" was fraudulent. Even though the story was full of scandalous details, it went largely unreported.  You let people believe the original story: that hydroxychloroquine routinely kills.

10.  You ensure federal agencies like FDA and CDC hew to your desired policies.  For example, FDA advised use only in hospitalized patients (too late) or in clinical trials (which are limited, are difficult to enroll in, or may use excessive doses).  As of mid June, FDA advises patients and doctors to only give the drug to patients if they are in a clinical trial where, presumably, the results can be controlled.

Another example:  you have FDA make unsubstantiated and false claims, such as:  "Hospitalized patients were likely to have greater prospect of benefit (compared to ambulatory patients with mild illness)" and claim the chloroquine drugs have a slow onset of action. If that were really true, they would not be used for acute attacks of malaria or in critically ill patients with Covid. (Disclosure:  I once dosed myself with chloroquine for an acute attack of P. vivax malaria, and it worked very fast.). Providing no other treatment advice, even though providing such information is a large part of its mission, CDC instead refers clinicians to the NIH guidelines, discussed below.

11.  You make sure to avoid funding/encouraging clinical trials that test drug combinations like hydroxychloroquine with zinc, with azithromycin, or with both, although there is ample clinical evidence that such combinations provide a cumulative benefit to patients.

12.  You have federal and UN agencies make false, illogical claims based on models rather than human data.  For example, you have the FDA state on June 15 that the dose required to treat Covid is so high it is toxic, after the Recovery and Solidarity trials have been exposed for toxic dosing.  This scientific double-speak gives some legal cover to the clinical trials that overdosed their patients. According to Denise Hinton, RN, the FDA's Chief Scientist (yes, a registered nurse without scientific qualifications is the Chief Scientist at FDA), or a clumsy FDA wordsmith: 

"Under the assumption that in vivo cellular accumulation is similar to that from the in vitro cell-based assays, the calculated free lung concentrations that would result from the EUA suggested dosing regimens are well below the in vitro EC50/EC90 values, making the antiviral effect against SARS-CoV-2 not likely achievable with the dosing regimens recommended in the EUA. The substantial increase in dosing that would be needed to increase the likelihood of an antiviral effect would not be acceptable due to toxicity concerns."

You have a WHO report claim toxic doses are needed. This is nonsense since: 

Toxicity was noted after only 3 days of treatment, during which 3.6 grams of chloroquine were administered. But the Solidarity (3.2 grams of hydroxychloroquine in 3 days), Recovery (3.6 grams  of hydroxychloroquine in 3 days) and REMAP-Covid trials (3.6 grams of hydroxychloroquine in 3 days) continued overdosing patients until June, despite Brazil's evidence of deaths by overdose.

Tellingly, JAMA editor Gordon Rubenfeld wrote after the Brazilian study came out in JAMA, "if you are prescribing HCQ after these JAMA results, do yourself and your defense lawyer a favor. Document in your medical record that you informed the patient of the potential risks of HCQ including sudden death and its benefits (???)." 

13.  You create an NIH Guidelines committee for Covid treatment recommendations, in which 16 members have or had financial entanglements with Gilead, maker of Remdesivir. The members were appointed by the Co-Chairs.  Two of the three Co-Chairs are themselves financially entangled with Gilead.  Are you surprised that their guidelines recommend specifically against the use of hydroxychloroquine and in favor of Remdesivir, and that they deem this the new "standard of care"?

14.  You frighten doctors so they don't prescribe hydroxychloroquine, if prescribing it is even allowed in their jurisdiction, because prescribing outside the new NIH "standard of care" leaves them open to malpractice lawsuits.  You further tell them (through the FDA) they need to monitor a variety of lab parameters and patient EKGs when using the drug, although this was never advised before, which makes it very difficult to use the drug in outpatients. You have the European Medicines Agency issue similar warnings.

15.  You manage to control the conduct of most trials around the world by specially designing the WHO-managed Solidarity trials, currently conducted in 35 countries. WHO halted hydroxychloroquine clinical trials around the world, twice.  The first time, May 25, WHO claimed it was in response to the (fraudulent) Lancet study.  The second time, June 17, WHO claimed the stop was in response to the Recovery trial results.  Recovery used highly toxic doses of hydroxychloroquine in over 1500 patients, of whom 396 died.  You stop the trial before the data safety monitoring board has looked at your data, a move that is unlikely to be consistent with trial protocol. WHO's trial in over 400 hospitals overdosed patients with 2.0 g hydroxychloroquine in the first 24 hours.  The trial was halted 3 days after the toxic doses were exposed (by me). The trial involved doctors around the world typing minimal patient information into an online WHO platform, which assigned the patient a treatment. The only "safety" information collected during the trial was whether patients required oxygen, required a ventilator, or died. This masked adverse effects of the drugs tested.  I should mention that WHO's initial plan for its Solidarity trial entirely omitted the chloroquine drugs, but they were added at the urging of participating nations. WHO's fallback position appears to have been to use toxic doses.

16.  You have the WHO pressure governments to stop doctors prescribing hydroxychloroquine. 

17.  You have the WHO pressure professional societies to stop doctors prescribing hydroxychloroquine.

18.  You make sure that the most-consulted US medical encyclopedia, UptoDate, advises physicians to restrict hydroxychloroquine to only clinical trials, citing the FDA.

19.  You have the head of the Coronavirus Task Force, Dr. Tony Fauci, insist the drug cannot be used in the absence of strong evidence...while he insisted exactly the opposite in the case of the MERS coronavirus outbreak several years ago, when he recommended an untested drug combination for use...which had been developed for that purpose by his agency.  And while he was bemoaning the lack of evidence, he was refusing to pay for trials to study hydroxychloroquine. And he was changing the goalposts on the Remdesivir trial, not once but twice, to make Remdesivir show a tiny bit of benefit, but no mortality benefit. And don't forget, Fauci was thrilled to sponsor a trial of a Covid vaccine in humans before there were any data from animal trials.  So much for requiring high quality evidence before risking use of drugs and vaccines in humans.

20.  You convince the population that the crisis will be long-lasting. You have the 2nd richest man in the world, and biggest funder of the WHO, Bill Gates, keep repeating to the media megaphone that we cannot go back to normal until everyone has been vaccinated or there is a perfect drug.  (The Gates Foundation helped design the WHO clinical trials, and Gates is heavily invested in Covid pharmaceuticals and vaccines.)

21.  You have CDC (with help from FDA) prevent the purchase of coronavirus test kits from Germany, China, WHO, etc, and fail to produce a valid test kit themselves. The result was that during January and February, US cases could not be tested, and for several months thereafter insufficient and unreliable test kits made it impossible to track the epidemic and stop the spread.

22.  You have trusted medical spokesmen lie to the public about the pandemic's severity, so precautions weren't taken when they might have been more effective and less long-lasting.  Congress was repeatedly briefed about the pandemic in January and February, which scared several Congress members enough that they sold off large amounts of stock, risking insider trading charges.  Senator Burr is one of them, currently under investigation for major stock sales on February 13.

Yet Dr. Fauci told USA Today on February 17 that Americans should worry more about the flu than about coronavirus, the danger of which was "just miniscule." Then on February 28, Drs. Fauci and Robert Redfield (CDC Director) wrote in the New England Journal:
"...the overall clinical consequences of Covid-19 may ultimately be more akin to those of a severe seasonal influenza (which has a case fatality rate of approximately 0.1%) or a pandemic influenza (similar to those in 1957 and 1968) rather than a disease similar to SARS or MERS, which have had case fatality rates of 9 to 10% and 36%, respectively."
23.  You destroy the reputation of respected physicians who stand in your way.  Professor Didier Raoult and his team in Marseille have used hydroxychloroquine on over 4,000 patients, reporting a mortality rate of about 0.8%.  (The mortality rate of patients given hydroxychloroquine in the Recovery trial was 25.7%.) Raoult is very famous for discovering over 100 different microorganisms, and finding the long-sought cause of Whipple's Disease.  With this reputation, Raoult apparently thought he could treat patients as he saw fit, which he has done, under great duress.  Raoult was featured in a New York Times Magazine article, with his face on the magazine cover, on May 12, 2020.  After describing his accomplishments, the Times very unfavorably discussed his personality, implied he conducted unethical trials without approval, and using anonymous sourcing produced a detailed hit piece. Raoult is now considered an unreliable crank in the US.

24.  You have social media platforms ban content that does not agree with the desired narrative.  As YouTube CEO and ex-wife of Google founder Sergey Brin, Susan Wojcicki said,

“YouTube will ban any content containing medical advice that contradicts World Health Organisation (WHO) coronavirus recommendations. Anything that would go against World Health Organisation recommendations would be a violation of our policy.”

25.  When your clinical trials are criticized for overdosing patients, you have Oxford-affiliated, Wellcome Trust-supported scientists at Mahidol University publish papers (a literature review with modeling and a modeling study) purporting to show that the doses used were not toxic. You develop a new method to measure hydroxychloroquine in a handful of Recovery patients who were not poisoned.  However, there are 2 problems you forgot with this approach: 
  • The Brazilian data, including 16 deaths, extensive clinical information and documented ventricular arrhythmias, are much more persuasive than a theoretical model of hydroxychloroquine pharmacokinetics.
  • Either the drug is too toxic to use, even at normal doses, for a life-threatening disease, or even extremely high doses are safe.  You can't have it both ways.
Oxford is the institution running the Recovery trial, and invented a Covid vaccine that already has 400 million doses on order.  The Wellcome Trust funded the Recovery trial.

26.  You change your trial's primary outcome measures after the trials have started, in order to prevent detection of drug-induced deaths (Recovery) or to make your drug appear to have efficacy (NIAID Remdesivir trial).

27.  You stop manufacturers from supplying the drug. Shortly after the fraudulent Lancet paper came out, Sanofi announced it would no longer supply the drug for use with Covid, and would halt its two hydroxychloroquine clinical trials. One of the cancelled Sanofi trials was expected to test 210 outpatients early in the course of disease. The trial remains suspended at the time of writing, while the Lancet paper was retracted 13 days after publication.  You surely don't want a trial of hydroxychloroquine treatment early in the disease, since it might show an excellent effect.


Aces&Eights said...

If I were to test positive where can I go? Who can I see that will treat me with "hydroxychloroquine" in the US, I believe in this therapy 1000%

A.C. Faraday

Meryl Nass, M.D. said...

It depends what your state or country allows. I would discuss it with your physician now, so you know how to manage if you get Covid-19

John said...

Tragic Beyond words! My compliments on your bold stand against this bigger then Goliath Monsters in your vision scope.

If it is not dangerous pesticides sprayed in record amounts often above limits in US, banned in eu for high cancer risk then it’s chemo and radiation for some cancers with no proven efficacy. Seeing when watching hopeless cancer patients one after the next walk the often ship hopeless planks overboards one after next dead again on chemo when known advanced stage metastasis liver carcinoma fancy term for “cancer” stage 3 and 4 chemo for chemo or no chemo about equal in ideal chemo conditions in current 5 yr survival rates yet on the chemo dead in months as known expected actually sicker chemo side effects.

In 2020 running towards Chief Sitting Bull a warrior cousin of Medicine Woman Physician Meryl Nass MD. Knees for the football games of laypeople as stricken patients with hindered physicians from those in charge nonetheless in positions to navigate medicine as critical patients often too sick to read through huge data bases if open to get to points of conflicting documentation. Perhaps case seeing another sent down the river to then make changes that bigger team of physicians may readily agree not in rare instances but large percentages in more and more diseases with less effective treatments in place from big pharma influence for business not cure. Especially of concern too supercomputers admitted programming interference online where people may not know conversations talking to are computer programs simulations of person when not with false profiles generation all over online as detailed in Facebook connection to CIA examples years after the fact. Thus, those extremely good looking profiles photos requesting to follow in friends was merely computer generated insults by CIA engineers and others Project Naomi programs in warped dishonesty intelligence agency litany of atrocities on citizens many documented many likely not. To where it gets to the point when calling your hospitals, push the 4 button if your in a coma from it all with Covid19 too?

Frankly the entire medical establishment is way out of bounds from fact after fact to anyone reading and focus attention on various aspects falling out of wack in areas that make ones head fall off here there and everywhere literally wonder if Big Pharma Metaphor for Nurse Ratchets in Jack Nicholson One Flew Over the Cuckoo's Nest, nowadays bulk of patients starring in Another One Flying Into big pharm’s Nurse Ratched’s meds Cuckoo NE$T$ insurance coverage whole body lobotomies guaranteed few seconds to say no if see?

Rotten Shenanigans HCV HDV WNV Lyme gW$ Cancer withheld 1987 PEP antidotes ongoing with California only PEP over the counter in 2020 that anyone could need if need for rape, huge increases in autism as the “new normal”, elder old folks home documentation often massive widespread corruption etc seemingly bigger and bigger. HCV quagmires where if lousy coverage different path with many deliberately not tested as high treatment cost unless better coverage maybe. Along with incomplete in public domain HCV HDV etc epidemiologies as perplexing too the sudden serious retroviruses popping up when labs coincidentally manipulated viruses particularly retroviruses as the science became available. Wuhan Covid19 most extraordinary peculiarities US and China dual operated lab with pursuant hide and seek charades following with better physicians including Meryl Nass calling olly olly oxen free!

TuvanDrone said...

Great summary of the fraud being perpetrated, Dr. Nass. You are welcome to use any of this additional information, without attribution, if you find it helpful:!Aq8aFLg55eqxgtEXNBDjPGR0v8Fd1w?e=RMGqot

(PDF - too big to post in comment)

Christopher said...

I telephoned my local pharmacist and asked if they stock hydroxychloroquine. They said yes they do, but they are not allowed to fill a RX for any other treatment than for what it is officially designated. In other words, they cannot fill a RX to treat COVID-19 as it is "off label". Since when can Dr's be prevented from prescribing medicines for off label treatments?

Meryl Nass, M.D. said...

It is really unprecedented. This AMA collection lists the rules each state put in place regarding hydroxychloroquine, last updated 4/27

Paul Picha said...

I'm sharing this info widely with my loved ones and friends. Thank you Dr. Nass

MaryP said...

WHO IS "YOU"????

Jerry said...

You fund "gain-of-function" research into coronaviruses, whose goal is to create new varieties that are highly infectious to human beings. Then you carry out the research in poorly secured Chinese laboratories, so that sooner or later there will be an "accidental" release. Then you write papers explaining that the released virus must have come from a food market.

Oliveoilguy said...

Dear Dr. Nass,
Thank you for compiling this list....I was aware of most of it because I’ve been following Peak Prosperity. There are a number of Doctors who contribute to the conversation and there is an excellent thread going called “Hydroxychloroquine vs. the deep state”. Your contribution would make this amazing forum that reaches 1/2 million people so much better.

John said...

Letter released from President Trump's physician. The letter states
does not have ‪#COVID19‬, while detailing that he is taking ‪#Hydroxychloroquine‬

Growing Unpopular Far Right Neo Fascists Brazil Leader Get US Hydroxychloroquine

Growing Unpopular leader in Brazil Called Neo Fascists on List In 2018

Certainly the White House Doc Could Call Press Conferences with Easily Assembled Team on Hydroxchloroquine as Prophylactics along with PEP too while at it, but certainly likely Neo Fascism Growing In Medicine for Decades likely Not Going to Care Happening Though Drop of a Pencil if any Trump needed PEP with Vegas Trip With Latest Neo Stormy Prescribed Pronto too while no ongoing “Neo normal” if raped or condom issue for teenager needs it in most places. Speaks for itself 4 years after 2016. Hitler concurs no doubt too.

For example, the central mechanism of action of hydroxychloroquine, and its effectiveness in combating COVID-19, can now be fully explained and understood. What this mechanism consists of is immediately stated: the drug, by binding itself permanently with ferriprotoporphyrin (of the Hb group Eme), removes the substrate from the viral proteins and also becomes an important means of prophylaxis. Although there are still no Italian publications on the effectiveness of hydroxychloroquine as a "shield" from the virus, among the directors of infectious disease departments, specialists, primary care physicians, and general practitioners contacted during this research, many have admitted – under the subheading – to using the drug as a “prophylaxis”, i.e., to prevent contagion.
Healthcare professionals who are in close contact with infectious patients take the drug, Hydroxychloroquine in advance, precisely to decrease the likelihood of infection. For now, there is a recent publication, involving 211 people, to support this ”prophylactic” effect. It was published in the International Journal of Antimicrobial Agents, the official organ of the International Society of Antimicrobial Chemotherapy. Of 211 people exposed to COVID-19 positive individuals and prophylaxis with hydroxychloroquine, none were infected.

Finally, further confirmation of this hypothesis is provided by the data collected in the register of the SIR (Italian Society of Rheumatology). In order to evaluate the possible correlations between chronic patients and COVID-19 SIR interviewed 1,200 rheumatologists throughout Italy to collect statistics on contagions. Out of an audience of 65,000 chronic patients (Lupus and Rheumatoid Arthritis), who systematically take Plaquenil/hydroxychloroquine, only 20 patients tested positive for the virus. Nobody died, and nobody is in intensive care, according to the data collected so far.

Unknown said...

Dear sir,
For me, this article is a confirmation of the fact that our health system is corrupt. That's why I decided two month ago, after reading the report of Dr Vladimir Zelenko healing 1400 outpatients of covid-19, to buy the medicines myself, without a doctor. I bought 100 gram HCQ in China at Alibaba ( 99.7 % HCQ, HPLC ), I bought pills of 50 mg zinc as zincgluconate, I bought Azithromycine on an English website. Then I bought empty HPMC-capsules type "1 " to fill each with 200 mg HCQ. Now I am prepared when the infection with covid-19 may come. My determination for action is inspired by the fact that I think the whole health system is corrupt. And this article confirms my thoughts. Thank you so much.

Unknown said...

Dear Madam,

I forgot to mention that the dispatching of HCQ was protected by calling the HCQ "White Pigment " So the customs inspection could not block the import of HCQ. They valued the product 10 USD to prevent import tax. I weighed the 200 mg HCQ per capsule type "1 " with a precision balance CT-250 ( 84 € ). But at arrival I checked the identity of the product by determination of the melting point.This has to be 240 degrees Celcius. I also measured 240 degrees Celcius. I appreciate your article very much. We need more people like you.
P.S. Sorry for calling you "sir" in my first comment