Tuesday, December 15, 2020

The spike protein of SARS-CoV-2 (what the mRNA vaccines cause our cells to produce) may be responsible for some of Covid's worst symptoms

This is the most thoughtful and erudite response I have seen to the experiment of turning humans into factories to make Covid (mutated) spike (S) protein.  Neither Pfizer, Moderna nor the FDA have commented in any publicly available documents on the serious safety questions this review of the literature raises.

Dr. Patrick Whelan, MD, PhD, formerly of Mass General Hospital and now UCLA, submitted the following letter about the mRNA vaccines to the FDA on December 8:

I am a pediatric specialist caring for children with the multisystem inflammatory syndrome (MIS-C). I am concerned about the possibility that the new vaccines aimed at creating immunity against the SARS-CoV-2 spike protein (including the mRNA vaccines of Moderna and Pfizer) have the potential to cause microvascular injury to the brain, heart, liver, and kidneys in a way that does not currently appear to be assessed in safety trials of these potential drugs.

Puntmann et al. (JAMA Cardiol. 2020;5:1265-1273) showed that the prospective study of 100 German patients who were recently recovered from COVID-19 revealed significant cardiac involvement on cardiac MRI scans in 78% of them, an average 2-1/2 months after their recovery from the acute illness. Two-thirds of these patients were never hospitalized, and there was ongoing myocardial inflammation in 60%. The abnormalities occurred independent of preexisting conditions, severity of the initial disease, and overall course of the acute illness.

Magro et al. showed that there is complement-mediated damage even in grossly normal skin of coronavirus-infected individuals (Human Pathology 2020:106:106-116). They have also shown (Magro et al. Annals of Diagnostic Pathology 2021:50 in press ) that ACE-2 receptor expression is highest in the microvasculature of the brain and subcutaneous fat, and to a lesser degree in the liver, kidney, and heart. They have further demonstrated that the coronavirus replicates almost exclusively in the septal capillary endothelial cells of the lungs and the nasopharynx, and that viral lysis and immune destruction of those cells releases viral capsid proteins (or pseudovirions) that travel through the circulation and bind to ACE2 receptors in these other parts of the body leading to mannan-binding lectin complement pathway activation that not only damages the microvascular endothelium but also induces the production of many pro-inflammatory cytokines. Meinhardt et al. (Nature Neuroscience 2020, in press) show that the spike protein in brain endothelial cells is associated with formation of microthrombi (clots), and like Magro et al. do not find viral RNA in brain endothelium. In other words, viral proteins appear to cause tissue damage without actively replicating virus.

Is it possible the spike protein itself causes the tissue damage associated with Covid-19? Nuovo et al (in press) have shown that in 13/13 brains from patients with fatal COVID-19, pseudovirions (spike, envelope, and membrane proteins) without viral RNA are present in the endothelia of cerebral microvessels. Furthermore, tail vein injection of the full length S1 spike subunit in mice led to neurologic signs (increased thirst, stressed behavior) not evident in those injected with the S2 subunit. The S1 subunit localizes to the endothelia of microvessels in the mouse brain, and is a potent neurotoxin. So the spike S1 subunit of SARS-CoV-2 alone is capable of being endocytosed by ACE2 positive endothelia in both human and mouse brain, with a concomitant pauci-cellular microencephalitis that may be the basis for the neurologic complications of COVID-19. The Pfizer/BioNTech vaccine (BNT162b2) is composed of an mRNA that produces a membrane-anchored full-length spike protein. The mouse studies suggest that an untruncated form of the S1 protein like this may cause a microvasculopathy in tissues that express much ACE2 receptor. A truncated form of S1 was much less damaging in mice.

While there are pieces to this puzzle that have yet to be worked out, it appears that the viral spike protein that is the target of the major SARS-CoV-2 vaccines is also one of the key agents causing the damage to distant organs that may include the brain, heart, lung, and kidney. Before any of these vaccines are approved for widespread use in humans, it is important to assess in vaccinated subjects the effects of vaccination on the heart (perhaps using cardiac MRI, as Puntmann et al. did). Vaccinated patients could also be tested for distant tissue damage in deltoid area skin biopsies, as employed by Magro et al. As important as it is to quickly arrest the spread of the virus by immunizing the population, it would be vastly worse if hundreds of millions of people were to suffer long-lasting or even permanent damage to their brain or heart microvasculature as a result of failing to appreciate in the short-term an unintended effect of full-length spike protein-based vaccines on these other organs.

Particular caution will be required with regard to the potential widespread vaccination of children before there are any real data on the safety or effectiveness of these vaccines in pediatric trials that are only now beginning.


Itch said...

From the beginning I have had a gnawing doubt about our focus on Covid19 death rates. The virus enters the cells through the ACE2 receptor, and this receptor is found on a variety of cells in the body, including testicular cells, so it was reported. Immediately I saw that I recalled the very serious impacts that mumps has on fertility when it infects mature men.

So just now, a report comes out that Covid19 seriously damages male germ cells:

"In all five COVID-19 patients, numerous degenerated germ cells (GCs) had sloughed into the lumen of seminiferous tubules (Fig. 1a). In contrast, in the age-matched control tissues, GCs at various stages were well aligned around the whole seminiferous tubules (Fig. 1a). Strikingly, in four of the five cases, GC loss was massive, with only a few GCs left attached to the seminiferous tubules. In particular, many seminiferous tubules in the testes of patients 4 and 5 showed almost no intact GCs, …. These morphological changes in the testes of COVID-19 patients indicate that SARS-CoV-2 infection may impair male GC development and eventually lead to GC loss."


This naturally leads to the question, Will it sterilize large numbers of men in the affected populations?

Meryl Nass, M.D. said...

The brain, kidneys, liver, heart are other organs that are being damaged. This can be a devastating illness when not treated with curative medications that kill the virus. Withholding these meds is criminal. This illness does not have to do this. The healthcare edifice is negligent--as if we told all our TB patients to go home, and after they had lost 30 lbs, then come in to hospital to be treated. Or telling our UTI patients to go home untreated and only come to the hospital if they get septic and delirious with temps above 103 degrees.

What we do not know, and neither Pfizer nor FDA is saying, is whether the vaccine-induced spike protein does cause some of the damage postulated to come from the viral-derived spike protein. They have been disingenuous about the side effects from the vaccine, providing no useful guidance on what to look for. (Instead, a list of side effects known to be caused by very different vaccines was chosen as thouse to be asked about.)

The active surveillance for side effects is primarily asking people to go to a mobile app and self report symptoms. It could potentially miss a lot.

Anonymous said...

For about ~ 1year of looking into bioinformatics of comparison between SARS-CoV-2 spike protein and MANY other proteins, I can tell only one,
in case the protein is indeed expressed in every cell, wait for its degradation, it's a tragedy. There are pieces of many toxic proteins related to bio-weapons: anthrax, botulin, rici, tetanus and more, there are many tiny pieces of human proteins, related to reproduction, believe system, metabolic processes, there are synthetic motifs in it to bind metals, synthetics, etc. The Mod-E-RNA research already years back indicated the goal of their modified mRNA'2, reprogramming human pluripotent cells, stem cells. Their products before 2020 were actually properly called gene-therapy agents, which they still are, just the name was 'rebranded' to 'vaccines' in order to make it 'acceptable' by the clueless citizens.