Most of the drugs (and most are already licensed) that are discussed have been featured in my previous blog posts. But now there is a more detailed physiologic explanation for how they work and how they might best be combined. Of special interest to me is the potential use of n-acetyl cysteine. This is an extremely safe drug, even at high doses, and is sold as an OTC supplement as well as a licensed drug in the US.
The penultimate page (#38 on the pdf, but pages are not numbered) has a diagram showing which viral and cellular processes are affected by the different drugs.
The paper also includes discussion of vaccines and blood products. There are 258 references. This is a must-read for anyone interested in improving Ebola clinical care, or designing Ebola drug trials. Here is the abstract:
Human Ebola Virus Infection in West Africa: a review of available therapeutic agents that target different steps of the life cycle of Ebola virus